David MacMillan

David William Cross MacMillan FRS FRSE (wobadwa pa 16 Marichi 1968) ndi wamankhwala waku Scotland komanso a James S. McDonnell University of Chemistry a University of Princeton, komwe adalinso Mpando wa department of Chemistry kuyambira 2010 mpaka 2015. Adagawana nawo Mphoto ya 2021 Nobel mu Chemistry ndi Benjamin List "yopanga asymmetric organocatalysis".

David MacMillan

Maphunziro ndi moyo woyambirira

MacMillan adabadwira ku Bellshill, Scotland mu 1968. Adalandira digiri yoyamba yaukadaulo ku chemistry ku University of Glasgow, komwe adagwira ntchito ndi Ernie Colvin.

Mu 1990, adachoka ku UK kuti ayambe maphunziro ake a udokotala motsogozedwa ndi Pulofesa Larry Overman ku Yunivesite ya California, Irvine. Munthawi imeneyi, adayang'ana kwambiri pakupanga njira zatsopano zomwe zimayendetsedwa ndikupanga ma bicyclic tetrahydrofurans. Maphunziro omaliza a MacMillan adafika pachimake pakuphatikizira kwa 7 - (-) - deacetoxyalcyonin acetate, eunicellin diterpenoid yotalikirana ndi coral yofewa ya Eunicella stricta. Adapeza Ph.D. mu 1996.

Adayamika momwe adaleredwa ku Scottish ngati chifukwa chomupezera Nobel.

Ntchito ndi kafukufuku

Atalandira Ph.D., MacMillan adalandira udindo ndi Pulofesa David Evans ku Harvard University. Maphunziro ake omwe adachita pambuyo pake anali okhudza enantioselective catalysis, makamaka, kapangidwe ndi kakulidwe ka Sn (II) -edived bisoxazoline complexes (Sn (II) box).

MacMillan adayamba kuchita kafukufuku wodziyimira pawokha ngati membala waukadaulo wa chemistry ku University of California, Berkeley mu Julayi 1998. Adalowa nawo department of chemistry ku Caltech mu June 2000, komwe kafukufuku wamagulu ake anali okhudzana ndi njira zatsopano zopangira katemera wa enantioselective. Mu 2004, adasankhidwa kukhala Earle C. Anthony Pulofesa wa Chemistry. Anakhala Pulofesa Wodziwika pa University of James S. McDonnell ku University of Princeton mu Seputembara 2006.

Amadziwika kuti ndi m'modzi mwa omwe adayambitsa organocatalysis. Mu 2000, MacMillan idapanga mamolekyulu ang'onoang'ono omwe amatha kupatsa kapena kuvomereza ma elekitironi motero kuwongolera machitidwe. Iye adapanga ma catalyst omwe amatha kuyendetsa asymmetric catalysis, momwe mayankho amapangira gawo lamanzere lamamolekyu kuposa lamanja, kapena mosemphanitsa. Gulu lofufuzira la MacMillan lapita patsogolo kwambiri pankhani ya asymmetric organocatalysis, ndipo agwiritsa ntchito njirazi zatsopano pakuphatikizika kwa zinthu zachilengedwe zosiyanasiyana. Adapanga chiral imidazolidinone othandizira. Ma MacMillan othandizira [de] amagwiritsidwa ntchito m'njira zosiyanasiyana. Zitsanzo ndi zomwe Diels-Alder reaction, 1,3-dipolar cycloadditions, Friedel-Crafts alkylations kapena Michael zowonjezera.

Pakati pa 2010 ndi 2014, MacMillan anali Woyambitsa Mkonzi wa magazini ya Chemical Science, mbiri yotchuka ya chemistry yofalitsidwa ndi Royal Society of Chemistry.